2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0686BR
    Eptifibatide acetate (Standard) 881997-86-0
    Eptifibatide (acetate) (Standard) is the analytical standard of Eptifibatide (acetate). This product is intended for research and analytical applications. Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity.
    Eptifibatide acetate (Standard)
  • HY-B0757AR
    (±)-α-Tocopherol nicotinate (Standard) 51898-34-1
    (±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].
    (±)-α-Tocopherol nicotinate (Standard)
  • HY-B1014S1
    Acenocoumarol-d4 2937878-24-3 98%
    Acenocoumarol-d4 is deuterium labeled Acenocoumarol (HY-B1014). Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist. Acenocoumarol inhibits MAPK/ERK/JNK signaling pathway, reduces the nuclear translocation of NF-κB p65, activates Akt/GSK3β signaling pathway. Acenocoumarol induces apoptosis in cell A549, arrests cell cycle at S phase.
    Acenocoumarol-d4
  • HY-B1092AR
    Gluconate sodium (Standard) 527-07-1
    Gluconate (D-Gluconic acid) (Standard) is the analytical standard of Gluconate sodium (HY-B1092A). This product is intended for research and analytical applications. Gluconate (D-Gluconic acid) sodium is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury.
    Gluconate sodium (Standard)
  • HY-B1191S1
    Nanofin-d5
    Nanofin-d5 (2,6-Lupetidine-d5) is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
    Nanofin-d5
  • HY-B1191SA
    Nanofin-d2 hydrochloride
    Nanofin-d2 (2,6-Lupetidine-d2) hydrochloride is the deuterium labeled Nanofin (HY-B1191). Nanofin (2,6-Lupetidine) is a neuro-blocking agent with antihypertensive effects, which can be used for the study of mild to moderate hypertension.
    Nanofin-d2 hydrochloride
  • HY-B1334AS
    Perhexiline-d11 maleate 98%
    Perhexiline-d11 (maleate) is the deuterium labeled Perhexiline maleate. Perhexiline maleate is a potent carnitine palmitoyltransferase 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively.
    Perhexiline-d11 maleate
  • HY-B1438S1
    Canrenone-d4 98%
    Canrenone-d4 is deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
    Canrenone-d4
  • HY-B1448AS
    (Rac)-Benidipine-d7 98%
    (Rac)-Benidipine-d7 is the deuterium labeled Benidipine. Benidipine is a potent and orally active calcium channel antagonist. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats.
    (Rac)-Benidipine-d7
  • HY-B1486AS
    Oxprenolol-d7 1189805-10-4 98%
    Oxprenolol-d7 is the deuterium labeled Oxprenolol. Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.
    Oxprenolol-d7
  • HY-B1538AR
    Bamethan hemisulfate (Standard) 5716-20-1
    Bamethan (hemisulfate) (Standard) is the analytical standard of Bamethan (hemisulfate). This product is intended for research and analytical applications. Bamethan (DL-Bamethane) hemisulfate is a vasodilator that exhibits significant activity in enhancing blood flow and reducing vascular resistance. Bamethan hemisulfate plays a crucial role in the treatment of cardiovascular conditions by improving oxygen delivery to tissues. Bamethan hemisulfate also aids in the management of hypertension through its relaxing effects on blood vessels.
    Bamethan hemisulfate (Standard)
  • HY-B1654AR
    Flavin adenine dinucleotide disodium salt (Standard) 84366-81-4
    Flavin adenine dinucleotide (disodium salt) (Standard) is the analytical standard of Flavin adenine dinucleotide (disodium salt). This product is intended for research and analytical applications. Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.
    Flavin adenine dinucleotide disodium salt (Standard)
  • HY-B1659S3
    Glycerol-d1 98%
    Glycerol-d is the deuterium labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis.
    Glycerol-d1
  • HY-B1751S1
    Quinidine-13C, d2 hydrochloride
    Quinidine-13C, d2 hydrochloride is the deuterium and 13C-labeled Quinidine (HY-B1302). Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM.
    Quinidine-13C, d2 hydrochloride
  • HY-B1836AR
    Meldonium dihydrate (Standard) 86426-17-7
    Meldonium (dihydrate) (Standard) is the analytical standard of Meldonium (dihydrate). This product is intended for research and analytical applications. Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor.
    Meldonium dihydrate (Standard)
  • HY-E70541A
    Bovine Factor IX 9001-28-9 98%
    Bovine Factor IX is prepared from freshly collected bovine plasma. Factor IX activated by the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Factor Xa.
    Bovine Factor IX
  • HY-E70544A
    Bovine Factor X 9001-29-0 98%
    Bovine Factor X is prepared from freshly collected bovine plasma and, after activation, can convert prothrombin to thrombin.
    Bovine Factor X
  • HY-E70544C
    Rabbit Factor X 9001-29-0 98%
    Rabbit Factor X is prepared from freshly collected rabbit plasma and, after activation, can convert prothrombin to thrombin.
    Rabbit Factor X
  • HY-E70547A
    Murine Factor XIII 9013-56-3 98%
    Murine Factor XIII is a natural coagulation factor present in plasma, composed of two identical α subunits and two identical β subunits.
    Murine Factor XIII
  • HY-E70554A
    Bovine Prothrombin 9001-26-7 98%
    Bovine Prothrombin is a glycoprotein with a molecular weight of 70 kDa and is composed of a single polypeptide chain. Prothrombin is activated by factors Va, Xa, and phospholipids to produce the serine protease thrombin.
    Bovine Prothrombin
Cat. No. Product Name / Synonyms Application Reactivity